lupus.bmj8d
Mezagitamab in systemic lupus erythematosus: clinical and mechanistic findings of CD38 inhibition in an autoimmune disease
Objective To evaluate safety and mechanism of action of mezagitamab (TAK-079), an anti-CD38 monoclonal antibody, in patients with moderate to severe systemic lupus erythematosus (SLE). Methods A phase ...
lupus.bmj8d
Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance
Objectives Activation of endosomal toll-like receptor (TLR)7 or TLR9 has been proposed as a critical step for the initiation and development of SLE. Traditional spontaneous lupus models normally ...
lupus.bmj8d
Cell of origin in diffuse large B-cell lymphoma in systemic lupus erythematosus: molecular and clinical factors associated with survival
Background SLE is associated with increased risk of diffuse large B-cell lymphoma (DLBCL). DLBCL is routinely classified by cell of origin (COO), with germinal centre B-cell (GCB) being more common ...
lupus.bmj7d
Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE
Background We examined the usefulness of erythrocyte-bound C4d (EC4d) to monitor disease activity in SLE. Methods Data and blood samples were collected from three different studies, each of which ...
lupus.bmj8d
LSO-080 Machine-learning approach on lupus low disease activity prediction
Background The development of lupus low disease activity state (LLDAS) as a treat-to-target endpoint for SLE patients has been validated. Its attainment has been associated with improved outcomes.
lupus.bmj3d
1101 Lysosome dysfunction and the accumulation of immune complexes associates with active disease in human systemic lupus erythematosus
Endosomes and lysosomes (endo-lysosomes) play a central role in maintaining cellular homeostasis by degrading extracellular and obsolete intracellular waste through their ability to acidify and ...
lupus.bmj6d
616 Comparison of optical and ultrasound imaging in lupus arthritis
1 Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, USA 2 Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, USA ...
lupus.bmj5d
LSO-041 Loss-of-function NADPH oxidase variants promote lupus pathogenesis by modulating B cell-intrinsic TLR signals
Background GWAS have linked loss-of-function mutations in phagocytic NADPH oxidase complex (NOX2) genes, including NCF1 and NCF2, to lupus pathogenesis. The prevailing model holds that reduced NOX2 ...
lupus.bmj8d
1104 Machine learning to determine the endotype of SLE patients: a validation study
Background We previously developed a novel machine learning (ML) pipeline leveraging analysis of gene expression data to identify subsets of SLE patients with common molecular patterns of disease or ...
lupus.bmj4d
Response to therapy at 6 months predicts long-term renal outcome in lupus nephritis with poor kidney function
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lupus.bmj8d
Lupus anticoagulant, disease activity and low complement in the first trimester are predictive of pregnancy loss
Introduction Multiple factors, including proteinuria, antiphospholipid syndrome, thrombocytopenia and hypertension, are predictive of pregnancy loss in systemic lupus erythematosus (SLE). In the ...
lupus.bmj8d
310 ELUCIDATE-Epigenetics; lupus urine cells in decoding APOL1 transmutation effect
Background/Purpose Systemic Lupus Erythematosus (SLE) is more common and severe in those of African Ancestry (AA) who, relative to Europeans, are twice as likely to develop lupus nephritis (LN). 1 ...