Researchers are exploring a new potential avenue for pancreatitis treatment: autophagy, a cellular recycling process.

In normal mice and humans, the blood sugar-regulating hormone insulin is produced by beta cells, while amylase, a digestive enzyme, is manufactured by acinar cells. The functions of acinar and ...

Pancreas biopsies are graded according to the following histologic criteria: degree of inflammation, eosinophilia, acinar inflammation, ductal inflammation, endothelialitis, and necrotizing arteritis.

These tumors form in the glandular cells that make prostate fluid. There are two types of adenocarcinoma: acinar adenocarcinoma and ductal adenocarcinoma. Acinar adenocarcinoma develops in the ...

Cerulein or alcohol impairs autophagy at multiple steps to promote pancreatitis. Cerulein or alcohol decreases pancreatic VMP1 to impair the closure of autophagosomes. Cerulein also decreases STX17 to ...

Age-old epidemiologic studies indicate that cancer is influenced by environmental factors. While some factors act by altering mutation rates, others work through epigenetic mechanisms that we suspect ...

In this study, we show that inhibition of focal adhesion kinase activity results in transdifferentiation of a subset of peri-islet acinar cells into functional insulin producing β-like cells.

CalciMedica Inc. ("CalciMedica") (Nasdaq: CALC), a clinical-stage biopharmaceutical company focused on developing novel calcium release-activated calcium (CRAC) channel inhibition therapies for acute ...