Cerulein or alcohol impairs autophagy at multiple steps to promote pancreatitis. Cerulein or alcohol decreases pancreatic VMP1 to impair the closure of autophagosomes. Cerulein also decreases STX17 to ...

University of Pittsburgh researchers Dr. Farzad Esni, Ph.D., and Jing Hu, Ph.D., did an experiment in mice where they deleted ...

The presence of acinar inflammation is essential for the histological diagnosis of adult NASH. Portal inflammation is increasingly recognized as an important feature of NASH, probably mediated by ...

In this study, we show that inhibition of focal adhesion kinase activity results in transdifferentiation of a subset of peri-islet acinar cells into functional insulin producing β-like cells.

Fluorescent imaging of acinar-derived insulin-producing cells (red and green) embedded among regular beta cells (green) in mice treated with a low dose of streptozotocin followed by a FAK ...

More intriguingly, they found a cluster of pancreatic cells simultaneously producing insulin and amylase—a phenomenon not observed under normal conditions, as insulin is typically produced by beta ...

5 Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, CIBEREHD, Barcelona, Spain Objective Pancreatic acinar cell ...

The transition from MPC to unipotent acinar progenitors is associated with c-Myc downregulation; a role for c-Myc in this process, and its possible relationship to a role in cancer, has not been ...

The pseudo-stratified columnar epithelium is progressively replaced by tall columnar cells in the proximal airways and cuboidal cells in the distal acinar structures. During the canalicular stage, ...