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Purpose. The pharmacology, efficacy, safety, and dosage and administration of bendamustine and its use in indolent non-Hodgkin's lymphoma (NHL) and chronic lymphocytic leukemia (CLL) are reviewed.

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Caution is advised in treating patients with mild or moderate renal impairment or mild hepatic impairment. [17] Bendamustine should not be used in patients with severe renal impairment (creatinine ...