In normal mice and humans, the blood sugar-regulating hormone insulin is produced by beta cells, while amylase, a digestive enzyme, is manufactured by acinar cells. The functions of acinar and ...

In normal mice and humans, the blood sugar-regulating hormone insulin is produced by beta cells, while amylase, a digestive enzyme, is manufactured by acinar cells. The functions of acinar and ...

Researchers are exploring a new potential avenue for pancreatitis treatment: autophagy, a cellular recycling process.

Cerulein or alcohol impairs autophagy at multiple steps to promote pancreatitis. Cerulein or alcohol decreases pancreatic VMP1 to impair the closure of autophagosomes. Cerulein also decreases STX17 to ...

[33] CFA is characterized by inflammation, damage, and progressive fibrosis in the acinar regions of the lungs, which suggests that genes that influence the processes of inflammation (eg ...

While better screening and improved treatments are leading to better outcomes for patients with breast cancer, 90% of breast cancer deaths are a result of metastasis, or the cancer growing and ...

Pancreatic ductal adenocarcinoma (PDAC) develops in the exocrine compartment of the pancreas, which is comprised of ductal and acinar cells. PDAC is associated with two major types of asymptomatic ...

† Number of splenic metastases found in the reports. ‡ Total number of autopsies/splenectomies/diagnostic procedures performed on cancer patients in each study ...

In this study, we show that inhibition of focal adhesion kinase activity results in transdifferentiation of a subset of peri-islet acinar cells into functional insulin producing β-like cells.

Salivary levels of thioredoxin were also significantly higher in patients with Sjögren's syndrome than in controls, and high levels of thioredoxin expression were observed in acinar cells of 13 ...

CalciMedica Inc. ("CalciMedica") (Nasdaq: CALC), a clinical-stage biopharmaceutical company focused on developing novel calcium release-activated calcium (CRAC) channel inhibition therapies for acute ...