University of Pittsburgh researchers Dr. Farzad Esni, Ph.D., and Jing Hu, Ph.D., did an experiment in mice where they deleted ...

The experiment, the results of which were published May 3 in Nature Communications, used a focal adhesion kinase-inhibiting drug that is being studied in cancer treatment. Researchers found that the ...

Researchers show that a FAK-inhibiting drug, which has been studied in cancer treatment, converted acinar cells into acinar-derived insulin-producing (ADIP) cells and helped regulate blood glucose in ...

A drug used for the treatment of pancreatic cancer can be repurposed to replace insulin therapy among people with diabetes, ...

Fluorescent imaging of acinar-derived insulin-producing cells (red and green) embedded among regular beta cells (green) in mice treated with a low dose of streptozotocin followed by a FAK ...

Pancreatic acinar cells form a heterogeneous population of new cell types in response to injury with the potential to limit or drive disease. Acinar-derived clones labeled in red and green.

Teenagers are less likely to drink, smoke or use drugs when their parents keep tabs on their activities—but not necessarily because kids are more likely to be punished for substance use ...

The presence of acinar inflammation is essential for the histological diagnosis of adult NASH. Portal inflammation is increasingly recognized as an important feature of NASH, probably mediated by ...

T cells—the body's foot soldiers against invaders, ranging from everyday infections to cancers—are integral to many successful immunotherapies. However, a frustrating factor is that ...

In this study, we show that inhibition of focal adhesion kinase activity results in transdifferentiation of a subset of peri-islet acinar cells into functional insulin producing β-like cells.