University of Pittsburgh researchers Dr. Farzad Esni, Ph.D., and Jing Hu, Ph.D., did an experiment in mice where they deleted one of two copies of the gene encoding an enzyme called focal adhesion ...

A drug used for the treatment of pancreatic cancer can be repurposed to replace insulin therapy among people with diabetes, ...

Researchers show that a FAK-inhibiting drug, which has been studied in cancer treatment, converted acinar cells into acinar-derived insulin-producing (ADIP) cells and helped regulate blood glucose in ...

The experiment, the results of which were published May 3 in Nature Communications, used a focal adhesion kinase-inhibiting drug that is being studied in cancer treatment. Researchers found that the ...

Pancreatic cancer, representing 3% of all cancer cases and 7% of cancer-related deaths in the US, is a serious health concern ...

In this study, we show that inhibition of focal adhesion kinase activity results in transdifferentiation of a subset of peri-islet acinar cells into functional insulin producing β-like cells.

Frontiers Science Center for Deep Ocean Multispheres and Earth Systems, Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education/Sanya Oceanographic Institution, Ocean ...

More intriguingly, they found a cluster of pancreatic cells simultaneously producing insulin and amylase—a phenomenon not observed under normal conditions, as insulin is typically produced by beta ...

5 Exocrine Pancreas Research Unit, Hospital Universitari Vall d'Hebron, Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, CIBEREHD, Barcelona, Spain Objective Pancreatic acinar cell ...

Fluorescent imaging of acinar-derived insulin-producing cells (red and green) embedded among regular beta cells (green) in mice treated with a low dose of streptozotocin followed by a FAK ...