Since their introduction over five decades ago, beta-blockers have revolutionized the landscape of cardiovascular medicine.

This result was surprising because previously xylazine was thought to only bind to the α 2-adrenergic receptor, and this finding could hint as to why withdrawal from fentanyl in combination with ...

Unregulated use of fentanyl and overdose deaths have increased dramatically in recent years, and this trend was made more ...

Over 100 new genomic regions linked to blood pressure were discovered, offering insights into iron metabolism and potential ...

In native cardiomyocytes, adrenergic and muscarinic receptors play crucial roles in mediating heart rate, conduction velocity, contractility, and cardiac hypertrophy. We investigated whether these ...

also called alpha-adrenergic blocking agents, work by interfering with the transfer of messages to specific parts of the body. Like other "blocker" medications, alpha blockers attach themselves to ...

From Abteilung für Pathophysiologie (G.H.) and Abteilung für Kardiologie (D.B.), Universitätsklinikum Essen, Essen, Germany; MRC Cyclotron Unit, Imperial College ...

The disparity in the results between the Metoprolol in Dilated Cardiomyopathy Trial and MERIT-HF raised the possibility that only extended- release metoprolol succinate is effective in treating ...