Herein, we will discuss this important autocrine-based cellular axis that parallels the hormonal-based hypothalamic–pituitary–testicular axis that regulates spermatogenesis. This local ...

Keros has engaged with the U.S. Food and Drug Administration regarding the design of the planned Phase 3 clinical trial of KER-050 in patients with myelodysplastic syndromes (“MDS”), and expect to ...

The most potent stimulus to collagen I production is TGF-beta, which is derived from both paracrine and autocrine sources. Lipid peroxidation products are emerging as important stimuli to ECM ...

In addition, it appears to function in a GH independent autocrine/paracrine mode in this tissue. 1 As information on the mechanisms that modulate muscle adaptation has been elucidated in the ...

Chemokines display autocrine, paracrine and hormonal roles in promoting cellular transformation, tumor growth, invasion and homing and metastasis to distant preferential organs (Fig. 1).

Cell production of substances such as catecholamines, acetylcholine and glutamate acting on their receptors, which allow autocrine/paracrine signalling, has been described,39 which may explain pain in ...

X. Zhang, S. Li, I. Malik, M.H. Do, L. Ji, C. Chou, W. Shi, K.J. Capistrano, J. Zhang, T. Hsu, B.G. Nixon, K. Xu, X. Wang, A. Ballabio, L.S. Schmidt, W.M. Linehan, M ...