In 1902, shortly after the rediscovery of Gregor Mendel's work by William Bateson 1 and just a few years after the word biochemistry was first coined, Archibald Garrod 2, a practicing physician at ...
In humans, the degradation of Phe and Tyr requires six enzymes. Homogentisate dioxygenase (HGO; E.C. 1.13.11.5) catalyzes the crucial aromatic ring opening reaction, utilizing nonheme Fe 2+ to ...