“An active daily exercise practice can have far-reaching benefits, which include enhanced neurocognitive function,” Fesharaki ...

Those folks are called “superagers.” And researchers have been trying for a long time to figure out what causes them to be ...

Having a gene that puts you at higher risk of a disease is not the same as a diagnosis, and Hemsworth wants people to ...

In a recent study, researchers suggest that a newly identified genetic variant may protect against Alzheimer's disease, ...

The APOE region or locus is a segment of DNA with several genes in close apposition, including APOE. Its boundaries are not strictly defined, spanning a stretch between 0.2 and 10 Mb long. In 5’ to 3’ ...

Researchers are looking at how microglia behave differently in the brains of people with Alzheimer's disease and with that knowledge develop new treatments.

The source of their passivity could result from a protein called APOE that is a component of amyloid plaques. The APOE proteins in the plaque bind to a receptor—LILRB4—on the microglia ...

ATP-binding cassette transporter A1 (ABCA1) mediates cholesterol efflux to lipid-free apolipoproteins such as apolipoprotein A-I (apoA-I) and apolipoprotein E (apoE). ABCA1 is essential regulator of ...

The FDA requires testing for the ApoE genetic biomarker before initiating Leqembi to inform patients and physicians of the risk of ARIA. Individuals with two copies of the ApoE mutation ...

The APOE proteins in the plaque bind to a receptor -- LILRB4 -- on the microglia surrounding the plaques, inactivating them, Yun Chen, co-first author on the study, explained.