The damaged DNA is first resected or cut to create single-stranded ends near the damaged site. These ends are then matched to ...

Human artificial chromosomes represent a revolutionary advancement in genetic engineering, offering unprecedented ...

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is ...

Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though ...

We are at a critical time and supporting science journalism is more important than ever. Science News and our parent organization, the Society for Science, need your help to strengthen scientific ...

The inactivation of one copy of the X chromosome in female mammals may start to fail as they get older, which may be why ...

Discoveries about PARP1 biology generate questions that could aid in development of new PARP1-targeting strategies.

The study, "Human telomere length is chromosome end-specific and conserved across individuals," was funded by grants from the National Institutes of Health (R35CA209974 to Greider and R01HL166265 ...

The emergence in the Neolithic of patrilineal social systems, in which children are affiliated with their father's lineage, ...

These scientists have developed an innovative technique for making artificial chromosomes that operate within human cells, opening unprecedented possibilities for genetic therapies, particularly ...

The development of patrilineal social systems during the Neolithic period, where children inherit their father's lineage, ...

Telomeres are found at the ends of chromosomes and play a critical role in the cell-renewal process. (Credit: National Human Genome Research Institute) We depend on our cells being able to divide and ...