A sufferer of acromegalic gigantism, this American man measured 2.49 m (8 ft 2 in). Koehler's twin sister was 74 cm (29 in) shorter than him, a difference that set a world record. The Tel Aviv ...

Nearly all patients have a prominent umbilicus or frank umbilical hernia. An acromegalic appearance with slight enlargement of the mandible, hands, and feet is common. After puberty, clitoromegaly ...

Figure 2. A patient with gigantism born in Magherafelt from 1910. Figure 3. Photograph from Garvagh museum showing 2 patients with typical features of acromegalic gigantism, the person the middle with ...

The pituitary tumour types occurring in these families are most commonly growth hormone-secreting adenomas (causing acromegaly or acromegalic gigantism), prolactin-secreting adenomas (prolactinomas) ...