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  1. Coordination of AMPA receptor trafficking by Rab GTPases

  2. Rab GTPases: The principal players in crafting the regulatory …

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    Rab4 and Rab11, which are implicated in the fast and slow recycling pathway, respectively 22, 23, are localized to separate membrane domains on early endosomes that are distinct from those harbouring Rab5 (ref. 20 ).
    Here, we identify GRIP-associated protein-1 (GRASP-1) as a neuron-specific effector of Rab4 and key component of the molecular machinery that coordinates recycling endosome maturation in dendrites. We show that GRASP-1 is necessary for AMPA receptor recycling, maintenance of spine morphology, and synaptic plasticity.
    journals.plos.org/plosbiology/article?id=10.1371/journal.p…
    Furthermore, Rab4 participates in a small GTPase cascade by promoting Arl1 recruitment to early endosomes, which supports the association of endosomal sorting sites with clathrin complexes and affects early endosomal sorting Rab proteins and their effectors in endocytic transport.
    www.sciencedirect.com/science/article/pii/S200103702200…
    Cormont M, Mari M, Galmiche A, Hofman P, Le Marchand Brustel Y (2001) A FYVE finger-containing protein, rabip4, is a rab4 effector protein involved in early endosomal traffic. Proc Natl Acad Sci U S A 98: 1637–1642. 55. Rehmann H (2005) Characterization and activation of the rab-specific exchange factor Epac by cyclic nucleotides.
    journals.plos.org/plosbiology/article?id=10.1371/journal.p…
  4. Anterograde Transport of Rab4-Associated Vesicles …

    webRab4. Kinesin-2α. Khc-73. axonal transport. Drosophila. ventral ganglion. synapse. Introduction. The apical compartment of a neuronal cell extends …

    • Author: Swagata Dey, Gary Banker, Krishanu Ray
    • Publish Year: 2017
  5. Crosstalk between the Rho and Rab family of small …

    webJan 27, 2023 · It was reported that Rab3A recycling machinery regulates the membrane binding of α-synuclein (Chen et al., 2013). Rab4 GTPases Canonical function. Rab4 is involved in cell secretion and metabolism via …

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  7. Rab5 and Rab4 Regulate Axon Elongation in the Xenopus Visual …

  8. Rab GTPases: The principal players in crafting the regulatory …

  9. Divalent Rab effectors regulate the sub-compartmental ... - Nature

  10. Cellular functions of Rab GTPases at a glance

  11. Toward a comprehensive map of the effectors of rab GTPases

  12. Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane